Endocrine Abstracts

Introduction: Pregnancy is rare in patients with Cushing Disease (CD) owing to ovulatory dysfunction. When surgery is not curative, medical treatment is usually considered. Ketoconazole and mitotane, commonly used medical therapies, have questionable teratogenicity and are not often options in pregnancy. Cabergoline was found to be effective in reducing hypercortisolism in Cushing’s disease. Observational studies suggested that low dose cabergoline treatment at the time o...

Introduction: Subclinical hypothyroidism (SCHT) in pregnancy has been associated with adverse obstetric and perinatal outcomes. However, few studies have investigated the evolution of postpartum thyroid function in women first diagnosed with SCHT in pregnancy (gestational SCHT).Objective: To determine the evolution of thyroid function (TF) and the clinical and biochemical factors related to the long-term persistence of hypothyroidism (HT) in women with g...

IntroductionPost parathyroidectomy cure in primary hyperparathyroidism (PHPT) is defined as normocalcemia six months after surgery. The frequency of persistent or recurrent post-surgical disease according to lengthy follow-up studies varies between 1% and 14%.ObjectiveTo determine if there is a subset of patients with cure criteria 6–12 months after parathyroidectomy that would not require long-term foll...

IntroductionThe association of autoimmune, nodular or neoplastic thyroid disease and primary hyperparathyroidism (PHPT) has been reported in 17 to 84% of cases. In the surgical treatment of PHPT, simultaneous thyroidectomy may be necessary to optimize surgical access and / or when there is abnormal thyroid pathology. On the other hand, an incomplete diagnosis in the previous study of PHPT increases the risk of not removing clinically significant thyroid ...